Children across the Middle East are exposed to "horrific violence" amid more than one month into the military escalation in the region, UNICEF warned Monday.

"Children in the region are being exposed to horrific violence, while the very systems and services meant to keep them safe are coming under attack," UNICEF Executive Director Catherine Russell said in a statement.

“Urgent action is needed by all parties to conflict to protect the lives of civilians and uphold the rights of children."

More than 340 children have reportedly been killed and thousands injured, according to UNICEF.

"Relentless attacks by parties to conflict across multiple countries are destroying and damaging the facilities and infrastructure that children depend on – including hospitals, schools, and water and sanitation systems," it said.

Across the region, more than 1.2 million children have been displaced, according to the statement.

UNICEF reiterated UN Secretary-General Antonio Guterres’ call for an "immediate cessation of hostilities and genuine de-escalation."

"Every party must exercise maximum restraint. Under international humanitarian law, civilians, including and especially children, and civilian objects must always be protected," it said.

Regional escalations have continued to rage since Israel and the US launched a joint offensive on Iran on Feb. 28, killing more than 1,340 people, including then-Supreme Leader Ayatollah Ali Khamenei.

Iran has retaliated with drone and missile strikes targeting Israel, Jordan, Iraq and Gulf countries hosting US military assets, causing casualties and damage to infrastructure while disrupting global markets and aviation.