Dr. Sabir Memon, head of the Trauma Center at Civil Hospital, told Anadolu that bodies of nine protesters with gunshots were brought to the facility.

Another 32 injured, he added, were being treated at the hospital, whereas at least eight were shifted to a private hospital by their families.

Two police constables were among the wounded, according to police surgeon Dr Summaiya Syed.

Police fired teargas and resorted to aerial firing as hundreds of protesters marched toward the US mission in the city's southern district.

Dozens managed to enter the consulate premises, smashed windows, and set fire to a portion of the reception, multiple videos shared on social media platforms showed.

Angry crowds also torched a police check post outside the consulate and burned tires.

Protests broke out in several other cities, including Lahore, where demonstrators clashed with police on their way to the US Consulate.

In the capital Islamabad, police blocked all roads leading to the Diplomatic Enclave that houses foreign embassies, including the US.

In a related development, the government of Sindh province, for which Karachi serves as the capital, formed a committee to investigate the clashes and killings of protesters.

Expressing sorrow and grief over the casualties, the government urged the protesters to lodge their protest "peacefully."