JERUSALEM/ISTANBUL

The Israeli city of Holon near Tel Aviv evacuated 746 people after their homes were severely damaged by an Iranian missile that struck the area Thursday morning, causing widespread destruction.

In the most severe attack since the Israel-Iran conflict began, 271 people were injured, including four seriously, across several areas in northern and central Israel in an Iranian missile strike early in the day, according to Channel 12.

The 746 people from 250 families were relocated from Holon after their homes were classified as "uninhabitable,” the Israeli Broadcasting Authority (KAN) reported.

One residential building was completely destroyed by the strike while varying degrees of damage occurred to four adjacent buildings amid a state of shock in the area, where the destruction was described as "massive,” added KAN.

Hostilities began last Friday when Israel launched airstrikes on several sites across Iran, including military and nuclear facilities, prompting Tehran to launch retaliatory strikes.

Israeli authorities said at least 25 people have been killed and hundreds injured since then in Iranian missile attacks.

Meanwhile, in Iran, 639 people have been killed and more than 1,300 wounded in the Israeli assault, according to Iranian media reports.