Dr. Sabir Memon, head of the Trauma Center at Civil Hospital, told Anadolu that bodies of nine protesters with gunshot wounds were brought to the facility, while another one died during treatment.

Another 31 injured, he added, were being treated, whereas at least eight were shifted to a private hospital by their families.

Two police constables were among the wounded, according to police surgeon Dr Summaiya Syed.

Police fired teargas and resorted to aerial firing as hundreds of protesters marched toward the US mission in the city's southern district.

Dozens managed to enter the consulate premises, smashed windows, and set fire to a portion of the reception, multiple videos shared on social media platforms showed.

Angry crowds also torched a police check post outside the consulate and burned tires.

Protests even broke out in several other cities, including Lahore, where demonstrators clashed with police on their way to the US Consulate.

Protesters also set a UN office on fire in Skurdu district of northern Gilgit-Baltistan region.

Shabbir Mir, a spokesman for the regional government, told Anadolu that the region is on "high alert" as protest demonstrations are underway in several districts.

In the capital Islamabad, police blocked all roads leading to the Diplomatic Enclave that houses foreign embassies, including the US.

The US Embassy in Islamabad urged its citizens in Pakistan to "observe good personal security practices, including being aware of your surroundings, avoiding large crowds, and ensuring your STEP registration is up to date."

Interior Minister Mohsin Naqvi said the government shares the grief of protesters, urging them to remain peaceful.

The government of Sindh province, for which Karachi serves as the capital, has formed a committee to investigate the clashes and killings of protesters.

Expressing sorrow and grief over the casualties, the government urged the protesters to lodge their protest "peacefully."